1. From the Departments of Geriatric Medicine (H.S.), Pediatrics (M. Yoshimoto, T.H., T.N.), and Cardiovascular Medicine (T.K.), Kyoto University Graduate School of Medicine, Japan; the Translational Research Center (Y.X., X.Z., T.M., M. Yokode), Kyoto University Hospital, Kyoto, Japan; and the RIKEN Center for Developmental Biology (S.N.), Kobe, Japan