1. From the Leducq Center for Cardiovascular Research (S.S., M.A., P.L.), Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass; the Department of Cardiovascular Medicine (S.S., S.N., H.O.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; and the Second Department of Internal Medicine (K.K.), Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.