1. From the Department of Cardiology (A.S.M.Z., J.W.J., L.M.H.), Leiden University Medical Center; TNO-Gaubius Laboratory (A.S.M.Z., L.S.M.B., T.K., J.J.E., L.M.H.), Biomedical Research Unit; Department of General Internal Medicine (L.S.M.B., L.M.H.), Leiden University Medical Center; Hemostasis and Thrombosis Research Center (B.J.M.vV.), Leiden University Medical Center, Leiden, The Netherlands; AstraZeneca (E.L., G.C.), Mölndal, Sweden.