Genetic Risk for Ischemic and Hemorrhagic Stroke

Author:

Yamada Yoshiji1,Metoki Norifumi1,Yoshida Hidemi1,Satoh Kei1,Ichihara Sahoko1,Kato Kimihiko1,Kameyama Takashi1,Yokoi Kiyoshi1,Matsuo Hitoshi1,Segawa Tomonori1,Watanabe Sachiro1,Nozawa Yoshinori1

Affiliation:

1. From the Department of Human Functional Genomics (Y.Y., S.I.), Life Science Research Center, Mie University, Tsu, Japan; Gifu International Institute of Biotechnology (Y.Y., Y.N.), Kakamigahara, Japan; Department of Internal Medicine (N.M.), Reimeikyo Rehabilitation Hospital, Minamitsugaru, Japan; Department of Vascular Biology (H.Y., K.S.), Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan; Departments of Cardiovascular Medicine (K.K., K.Y.) and Neurology (T.K.),...

Abstract

Objective— We performed an association study to identify gene polymorphisms for assessing the genetic risk of ischemic or hemorrhagic stroke. Methods and Results— The study population comprised 3151 unrelated Japanese individuals: 1141 stroke patients (636 with atherothrombotic cerebral infarction, 282 with intracerebral hemorrhage, and 223 with subarachnoid hemorrhage) and 2010 controls. The genotypes for 202 polymorphisms of 152 genes were determined by suspension array technology. Multivariable logistic regression analysis with adjustment for conventional risk factors revealed that the –572G→C polymorphism of the interleukin-6 (IL-6) gene ( IL6 ) was significantly ( P <0.001) associated with both atherothrombotic cerebral infarction and intracerebral hemorrhage and that the –55C→T polymorphism of the uncoupling protein 3 gene ( UCP3 ), the –863C→A polymorphism of the tumor necrosis factor (TNF) gene ( TNF ), and the G→A (Gly243Asp) polymorphism of the polycystic kidney disease 1–like gene ( PKD1-like ) were significantly associated with subarachnoid hemorrhage. Conclusions— IL6 genotype may be useful in assessing the genetic risk for atherothrombotic cerebral infarction and intracerebral hemorrhage, and genotypes for UCP3 , TNF , and PKD1-like may be similarly beneficial in assessment of the risk for subarachnoid hemorrhage. Validation of our findings will require additional studies with independent subject panels.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Reference32 articles.

1. American Heart Association. Heart Disease and Stroke Statistics—2005 Update. Dallas Texas: American Heart Association; 2005.

2. Mortality by cause for eight regions of the world: Global Burden of Disease Study

3. High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR–SSOP–Luminex method in the Japanese population

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