1. From the Department of Pathology (A.P.J.J.B., E.L., M.J.A.P.D.), Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht; the Department of Population Genetics (T.A.), Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht; the Division of Biopharmaceutics (J.K.), Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden; and the Department of Medical Biochemistry (A.J.H.), Academic Medical Center, University of Amsterdam, The Netherlands.