Prostigmine Inhibition of Ventricular Fibrillation in the Hypothermic Dog-Reference-Cited by-同舟云学术

Prostigmine Inhibition of Ventricular Fibrillation in the Hypothermic Dog

Published:1954-11 Issue:5 Volume:10 Page:721-727
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

MONTGOMERY A. V.¹,PREVEDEL ARTHUR E.¹,SWAN HENRY¹

Affiliation:

1. From the Departments of Physiology and Surgery, and the Halsted Laboratory of Experimental Surgery, University of Colorado Medical School, Denver, Colo.

Abstract

This study shows that when prostigmine is given via coronary perfusion in the hypothermic dog, cardiac surgery can be performed without ventricular fibrillation resulting. This action of prostigmine seems to be due to an accumulation of acetylcholine, since prostigmine's antifibrillatory action can be reproduced by a continuous coronary perfusion of acetylcholine or by stimulation of the vagus nerve. A possible relationship between potassium and ventricular fibrillation is discussed.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.10.5.721

Reference16 articles.

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2. GENERAL HYPOTHERMIA FOR EXPERIMENTAL INTRACARDIAC SURGERY

3. Influence of intraventricular catheters on the course of immersion hypothermia in the dog;HEGNAUER A. H.;Am. J. Physiol.,1951

4. Ventricular fibrillation induced by cold

5. ITS POSSIBLE ROLE IN CARDIAC SURGERY

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