Affiliation:
1. From the Division of Medicine of the University of California School of Medicine, San Francisco.
Abstract
Blood quinidine determinations by the photofluorometric method were made in 30 patients with auricular fibrillation or flutter in whom conversion to sinus rhythm was attempted. Successful conversion occurred in 82 per cent of the patients, with a mean blood level of 5.9 mg./liter. Vomiting and, in one case, ventricular tachycardia were the most important toxic manifestations. Doses of 0.4 to 0.6 Gm. every two hours for five doses daily were usually adequate to obtain the average conversion blood level. The importance of the quantitative aspects of quinidine therapy and the relation of time, dose and concentration of quinidine in the blood are discussed.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference25 articles.
1. LwlIS; T. I)RURY A. N. WEED A. AND ILIESCU C. C.: Observations upon the action of certain (Irugs upon fibrillation of the auricles. Heart: 9: 207 1922.
2. Quinidine treatment of auricular fibrillation;PARKINSON J.;Quart. J. Med.,1929
3. AN EVALUATION OF THE USE OF QUINIDINE SULPHATE IN PERSISTENT AURICULAR FIBRILLATION
4. KERR W. J.: Use of quinidine in cardiac irregularities. The Encyclopedia of Medicine Surgery and Specialties. Philadelphia F. A. Davis Co. 1939. Pp. 922-943.
5. Quinidine in the treatment of benign auricular fibrillation with repeated emboli
Cited by
115 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. History of the Bioavailability–Bioequivalence Concepts;Revising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Time Concept;2023
2. On-Site Therapeutic Drug Monitoring;Trends in Biotechnology;2020-11
3. Clinical Pharmacology of Antiarrhythmic Drugs;Cardiovascular Therapeutics: A Companion to Braunwald's Heart Disease;2013
4. Principles of Clinical Pharmacology;Electrophysiological Disorders of the Heart;2012
5. Evaluation of Quinidine Lipettes®- a Sustained Release Preparation;Acta Medica Scandinavica;2009-04-24