A Comparison of the Serum Lipids, Lipoproteins, Glycoproteins, Urinary 17-Ketosteroids, and Gonadotropins in Eunuchs and Control Male Subjects

Author:

FURMAN ROBERT H.1,HOWARD R. PALMER1,SHETLAR M. R.1,KEATY E. CORINNE1,IMAGAWA RICHARD1

Affiliation:

1. From the Cardiovascular Section and the Endocrinology and Metabolism Section, Oklahoma Medical Research Foundation, the Departments of Medicine and Biochemistry, University of Oklahoma School of Medicine and the Research Laboratory, V. A. Hospital, Oklahoma City, Okla.

Abstract

The proclivity of men to coronary artery disease has been recognized for almost 2 centuries. The gonadal hormones have understandably come under scrutiny in the search for the explanation of this marked sex difference in susceptibility to disease. Sex hormones are known to alter the physical state of the serum lipids. It has been suggested that eunuchs suffer a less severe form of coronary atherosclerosis than uncastrated subjects. This study compares the serum lipids and lipoproteins, as well as other serum and urinary constituents, in 24 castrated and 20 uncastrated institutionalized men.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference24 articles.

1. HEBERDEN W.: "Commentaries on the History and Cure of Diseases" published posthuimously in London 1802; taken from "Cardiac Classics" by F. A. Willius and T. E. Keys. St. Louis the C. V. Mosby Company 1941.

2. The Degree of Coronary Atherosclerosis in Bilaterally Oophorectomized Women

3. The Incidence and Severity of Atherosclerosis in Estrogen-Treated Males, and in Females with a Hypoestrogenic or a Hyperestrogenic State

4. Discussion of paper by BARR, D. P., Russ, E. M., AND EDER, H. S.: Influence of estrogens on lipoprotein in atherosclerosis;WHITE P. D.;Tr. A. Am. Physicians,1952

5. Ketosteroids in coronary heart disease;HOWARD R. R.;J. Kansas M. Soc.,1953

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