Relationship between Diuretic and Antihypertensive Effects of Chlorothiazide and Mercurial Diuretics-Reference-Cited by-同舟云学术

Relationship between Diuretic and Antihypertensive Effects of Chlorothiazide and Mercurial Diuretics

Published:1959-06 Issue:6 Volume:19 Page:827-838
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

HOLLANDER WILLIAM¹,CHOBANIAN ARAM V.¹,WILKINS ROBERT W.¹

Affiliation:

1. From the Robert Dawson Evans Memorial Department of Clinical Research and Preventive Medicine, Massachusetts Memorial Hospitals and the Department of Medicine, Boston University School of Medicine, Boston, Mass.

Abstract

Both chlorothiazide and parenteral mercurial diuretics have an antihypertensive as well as a natriuretic action. Previous observations have suggested that the antihypertensive effect is not due solely to sodium depletion. This paper expands these observations on a larger group of normotensive and hypertensive subjects and presents new studies on the effects of fluorohydrocortisone and SC-8109 (a "steroidal antagonist"), upon the sodium excretion and blood pressure of hypertensive patients during treatment with one of the diuretics.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.19.6.827

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