The Rate of Disappearance of Lanatoside C. and Digitoxin from the Blood of Rats

Author:

BINE RENÉ1,FRIEDMAN MEYER1,BLAND CATHERINE1

Affiliation:

1. From The Mount Zion Hospital, The Harold Brunn Institute for Cardiovascular Research, San Francisco, Calif.

Abstract

By means of the embryonic duck heart preparation, both lanatoside C. and digitoxin could be detected and quantitatively measured in the sera of rats after parenteral administration of both drugs. A study of the behavior of the two glycosides in blood indicated that a striking difference existed in the respective rates of disappearance of both drugs from the bloodstream.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference4 articles.

1. A STUDY OF THE RATE OF DISAPPEARANCE OF A DIGITALIS GLYCOSIDE (LANATOSIDE C.) FROM THE BLOOD OF MAN 1

2. Employment of the Embryonic Duck Heart for the Detection of Minute Amounts of a Digitalis Glycoside (Lanatoside G)

3. Observations concerning the effect of blood upon the action of a. digitalis glycoside. Am. J. M\I;BINE R.;SC.,1948

4. 4FRIEDMAN I\1. BINE R. JR. AND BYERS S. 0.: Urinary excretion of (ligitoxin in the rat. Proc.

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1. Kinetik der Herzsteroide im Organismus des Menschen und der Versuchstiere;Klinische Wochenschrift;1970-03

2. Extrakardiale digitaliswirkungen;Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie;1961-12

3. Über die Verteilung herzglykosidspaltender Fermente im tierisehen Organismus;Naunyn-Schmiedeberg's Archiv für Experimentelle Pathologie und Pharmakologie;1960-10

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5. The Clinical Use of Digitalis Preparations;Circulation;1955-08

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