Affiliation:
1. From the Medical Research Laboratory of the Beth Israel Hospital and the Department of Pharmacology, Harvard Medical School, Boston, Mass.
Abstract
The action of two pure veratrum alkaloids, veratridine and protoveratrine, in human hypertension is described for the first time. The vasodepressor reflex pathway involved in the response to these ester alkaloids is reviewed. Protoveratrine is found to produce a striking fall in blood pressure in both essential and renal hypertension after intravenous administration.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
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