Comparison of Large and Small Doses of Hormones in the Treatment of Acute Rheumatic Carditis

Author:

ROY SUJOY B.1,MASSELL BENEDICT F.1

Affiliation:

1. From the House of the Good Samaritan, Children's Medical Center and the Department of Pediatrics, Harvard Medical School, Boston, Mass.

Abstract

Disappearance of significant murmurs was twice as common in 47 rheumatic children treated with large doses of hormones as in a comparable group of 41 children treated with small doses of hormones. Results were also related to the duration of illness before therapy was started. The findings suggest that the divergencies of opinion regarding the efficacy of hormones in the treatment of acute rheumatic carditis may in part be explained on the basis of differences in doses of hormones, in duration of therapy, and in duration of illness before the beginning of therapy.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference3 articles.

1. HENCH P. S. SLOCUMB C. H. B.\11xI.S A. II. SMITH H. L. POLLE-Y H. F. AND KE1NDALL. 11. C.: Effects of adrenal (orti(al lironie 17- hvdroxv- 1-dehvdr(ocorticosterone (compouind E1) on the acute p)hase of rheumatic fever: p)reliminaly report. Proc. Staff \ leeting \11ayo Clinic 24: 277 1949.

2. 2M\ASSELL B. F.: ACTH and cortisone therapy of rheumatic fexver and rheumatic (arilitis. New England J. \Med. 251: 183 221 and 263 1954.

3. The treatment of acute rheumatic fever in children. A (ooperative clinical trial of ACITH, (cotisonie anf(l aspirin;Circultation,1955

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