Affiliation:
1. From the Research Division of The Cleveland Clinic Foundation and The Frank E. Bunts Educational Institute, Cleveland, Ohio.
Abstract
The pathogenesis of flushing attacks in patients with malignant carcinoid tumors is attributed to the direct pharmacologic effect of excessive amounts of circulating serotonin. It was hoped that potent serotonin antagonists might relieve symptoms of the carcinoid syndrome in the inoperable patient. The nature of flushing attacks was studied in carcinoid patients and the influence thereon of 3 serotonin antagonists, a benzyl analog of serotonin, bromo-lysergic acid diethylamide, and chlorpromazine. The systemic, subjective, and vascular effects of these antagonists in normal subjects were also investigated.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference44 articles.
1. Purification of the substance which is responsiblc for vasoconstrictor activity of serum;RAPPORT M. M.;Fed. Proc.,1947
2. Partial purification of vasoconstrictor in beef serum;AND;J. Biol. Chem.,1948
3. 1RAPPORT M. M. GREEN A. A. AN1) PAGE I. H.
Science 108: 329 1948.
4. Serum vasoconstrictor (serotonin): IV. Isolation and characterization. .;AND;J. Biol. Chem.,1948
5. Serum vasoconstrictor (serotonin); presence of creatinine in the complex. A. propose(l structure of the vasoconstrictor principle. .1;Biol. Chem.,1949
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