Affiliation:
1. From the Department of Medicine and the University Hospital of the College of Medicine, State University of Iowa, Iowa City, Ia.
Abstract
Recent papers by Biörck and Rosenbaum have revived interest in the rare disease characterized pathologically by carcinoid of the small intestine, metastases to the liver, acquired nonrheumatic disease of the tricuspid and pulmonic valve, and angiomas in the skin. Clinically the condition is characterized by dramatic episodes of flushing, mottling of the skin, diarrhea, dyspnea and ultimately by congestive failure. Probably 5-hydroxytryptamine (serotonin) liberated from the carcinoid tumors induces the vascular changes. The suggestion is set forth that an antagonist to this compound might reduce the symptoms and perhaps favorably affect the course of the disease. Two cases are reported.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
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