Physical Factors in the Progression of Stenotic Vascular Lesions-Reference-Cited by-同舟云学术

Physical Factors in the Progression of Stenotic Vascular Lesions

Published:1958-03 Issue:3 Volume:17 Page:410-417
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

RODBARD SIMON¹

Affiliation:

1. From the University of Buffalo, Chronic Disease Research Institute, Buffalo, New York, and the Cardiovascular Department, Medical Research Institute, Michael Reese Hospital, Chicago, Ill.

Abstract

An explanation of the progression of stenotic lesions was sought in animal experiments. After surgical decrease of the lumen of arteries, progressive ingrowth of fibrous connective tissue led to the development of stenosis with changes in the artery that resembled those of coarctation. These changes are explained by the action of local blood pressures. Phenomena such as progressive stenosis, valvulogenesis, patterns of lipid infiltration, medial hypertrophy, thinning, and cystic change are discussed in terms of the concepts derived from these studies.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.17.3.410

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