Effects of Chlorothiazide on Specific Renal Functions in Hypertension

Author:

CORCORAN A. C.1,MACLEOD CATHEL1,DUSTAN HARRIET P.1,PAGE IRVINE H.1

Affiliation:

1. From the Research Division, Cleveland Clinic Foundation, Frank E. Bunts Educational Institute, Cleveland, Ohio.

Abstract

Oral administration of chlorothiazide depresses glomerular filtration, increases blood urea, maintains sodium output in the face of decreased filtered sodium load, and paradoxically for a diuretic, in these and in tests done shortly after intravenous administration, increases the efficiency of water reabsorption.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference13 articles.

1. A Mechanism of Chlorothiazide-Enhanced Effectiveness of Antihypertensive Ganglioplegic Drugs

2. Chlorothiazide and other diuretic drugs. Ed. Whitelock, O.v.;St. Ann. New York Acad. Se.,1958

3. RENAL FUNCTION IN PRIMARY ALDOSTERONISM 1

4. SMITH H. W.: Principles of Renal Physiolocry. New York Oxford University Press 1956.

5. EFFECTS OF HYPOTENSION DUE TO HEMORRHAGE AND OF BLOOD TRANSFUSION ON RENAL FUNCTION IN DOGS

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