1. From the Departments of Medicine and Aging (F. Cipollone, P.P., M.P., G.D., F. Cuccurullo, C.P.) and Biomedical Sciences (T.B.), University of Chieti “G. D’Annunzio” School of Medicine, Chieti, Italy; Department of Pharmacology (G.C.), Catholic University School of Medicine, Rome, Italy; and the Division of Cardiology (D. Di G.), “F. Renzetti” Hospital, Lanciano, Italy.