1. From the Department of Clinical Epidemiology and Biostatistics (B.J.O., R.G., G.B., A.W., R.S.R., M.G.) and the Department of Medicine (S.J.C.), McMaster University, Hamilton, Ontario, Canada; Centre for Evaluation of Medicines (B.J.O., R.G., G.B., A.W.), St. Joseph’s Hospital, Hamilton, Ontario, Canada; Department of Medicine (R.Y.), University of Western Ontario, Hamilton, Ontario, Canada; and Hamilton Civic Hospitals Research Centre (R.S.R., M.G.), Hamilton, Ontario, Canada.