Expression and Function of PPARγ in Rat and Human Vascular Smooth Muscle Cells

Author:

Law Ronald E.1,Goetze Stephan1,Xi Xiao-Ping1,Jackson Simon1,Kawano Yasuko1,Demer Linda1,Fishbein Michael C.1,Meehan Woerner P.1,Hsueh Willa A.1

Affiliation:

1. From the Department of Medicine (R.E.L., S.G., X.-P.X., S.J., Y.K., L.D., W.P.M., W.A.H.); the Division of Endocrinology, Diabetes, and Hypertension (R.E.L., S.G., X.-P.X., Y.K., W.P.M., W.A.H.); the Division of Cardiology (S.J., L.D.); and the Department of Pathology and Laboratory Medicine (M.C.F.), University of California at Los Angeles School of Medicine.

Abstract

Background —Peroxisome proliferator–activated receptor-γ (PPARγ) is activated by fatty acids, eicosanoids, and insulin-sensitizing thiazolidinediones (TZDs). The TZD troglitazone (TRO) inhibits vascular smooth muscle cell (VSMC) proliferation and migration in vitro and in postinjury intimal hyperplasia. Methods and Results —Rat and human VSMCs express mRNA and nuclear receptors for PPARγ1. Three PPARγ ligands, the TZDs TRO and rosiglitazone and the prostanoid 15-deoxy-Δ 12,14 -prostaglandin J2 (15d-PGJ2), all inhibited VSMC proliferation and migration. PPARγ is upregulated in rat neointima at 7 days and 14 days after balloon injury and is also present in early human atheroma and precursor lesions. Conclusions —Pharmacological activation of PPARγ expressed in VSMCs inhibits their proliferation and migration, potentially limiting restenosis and atherosclerosis. These receptors are upregulated during vascular injury.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3