Nephrogenic Hypertension (Goldblatt Kidney) Following Operative Trauma to the Renal Artery

Abstract

The thrombosis of the right renal artery following operative injury set off a chain of events closely duplicating the arterial hypertension observed by Goldblatt after constriction or occlusion of the renal arteries in experimental animals. The resulting hypertension was severe, fulminating, prolonged, and resistant to treatment by hypotensive and ganglion-blocking agents; it was associated with pulmonary edema, myocardial infarction, and impairment of the renal function. Nephrectomy brought about a return of the blood pressure to normal levels. The concentration of renin in the removed kidney was 34 times greater than normal.