Affiliation:
1. From the Department of Medicine and Harold Brunn Institute for Cardiovascular Research, Mount Zion Hospital, San Francisco, Calif.
Abstract
The gastrointestinal symptoms of quinidine toxicity occurred without relation to plasma concentration, suggesting that most examples are due to individual local gastrointestinal sensitivity and some, associated with giddiness, occur only at higher levels and may be due to nervous system effects. Tinnitus, visual disturbances and marked hypotension generally occurred at relatively high plasma quinidine concentrations. It is suggested that hypotension is due to a nervous system effect rather than to myocardial incompetence, but nonetheless warrants cessation of administration.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference18 articles.
1. THROMBOPENIC PURPURA FOLLOWING QUINIDINE
2. following two doses of 0.2 Gm. quinidine sulfate orally
3. have been observed since this paper has been sent to
4. press. Such phenomena should be classed as idio
5. syncrasies. Although not encountered in this series
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