Dissecting Aneurysm Produced by Diet

Author:

BEAN WILLIAM B.1,PONSETI IGNACIO V.1

Affiliation:

1. From the Departments of Orthopedics and Internal Medicine and The University Hospitals of the College of Medicine, State University of Iowa, Iowa City, Ia.

Abstract

Spontaneous dissecting aneurysm of the aorta in man is most commonly a sequel of hypertension but sometimes occurs in association with degenerative liquefaction of the media of the aorta. New light has been thrown upon dissecting aneurysm by its production in growing rats by a diet high in sweet peas. The offending agent has been isolated and a number of simpler related compounds have been synthesized and found effective. The relationship of this syndrome to a spontaneous dissecting aneurysm of the aorta in man is reviewed and some suggestions are made for investigation which may lead to newer methods of therapy.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference17 articles.

1. Experimental medionecrosis of the aorta;SCHLICHTER J. G.;Arch Path.,1946

2. DISSECTING ANEURYSMS OF THE AORTA

3. Scoliosis and dissecting aneurysm of the aorta in rats fed with lathyrus odoratus seeds;PONSETI I.;Am. J. Path.,1952

4. 4- AND SHEPARD R. S.: Lesions of the skeleton and of other mesodermal tissues in rats fed sweet-pea (lathyrus odoratus) seeds. J. Bone & Joint Surg. 36-A: 1031 1954. BEAN W. B. AND PONSETI I. V.: Dissecting aneurysm produced by diet: some relations to arachnodactyly and kyphoscoliosis. Proceedings Second World Congress Cardiology 2 389 1954.

5. STOCKMAN , R. : Lathyrism. J. Pharmacol. 37 : 43 , 1929 .

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