The Problem of Bioassay and Comparative Potency of Diuretics

Author:

FORD RALPH V.1,SPURR CHARLES L.1,MOYER JOHN H.1

Affiliation:

1. From the Veterans Administration Hospital and the Departments of Medicine and Pharmacology of Baylor University College of Medicine, Houston, Tex.

Abstract

Oral diuretic agents are widely used with but little information concerning their relative diuretic and toxic effects. A method is reported here for the bioassay of oral diuretic agents so that their comparative potency may be established. Four carbonic anhydrase inhibitors are compared by this method.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference5 articles.

1. FORD R. V. AND -MOYER J. H.: I)iurctic therapy. Current concepts of the use of diuretics with emphasis on the methods of selection of the agent of choice. In press.

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3. Sulphanilamide as a Specific Inhibitor of Carbonic Anhydrase

4. FORD R. V. SPURR C. L. AND MOYER .J. H.: The problem of bioassay and comparative pot(eni(c.y of diuretics. I. Parenteral and oral mercurial diuretics. To be published.

5. 5_

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1. Diuretic and Uricosuric Agents;Burger's Medicinal Chemistry and Drug Discovery;2003-01-15

2. C;Hagers Handbuch der Pharmazeutischen Praxis;1993

3. THERAPY WITH COMBINATIONS OF DIURETIC AGENTS: COMPARATIVE STUDIES;Annals of the New York Academy of Sciences;1966-11

4. Klinische Prüfung eines neuen Sulfonamiddiuretikums;DMW - Deutsche Medizinische Wochenschrift;1961-12

5. IMIDAZOLE SULPHONAMIDES AND RELATED COMPOUNDS;Canadian Journal of Chemistry;1961-06-01

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