Affiliation:
1. From the Department of Pharmacology, Boston University School of Medicine, Boston, Mass.
Abstract
Ventricular tachycardia has been produced in unanesthetized dogs by the intravenous injection of ouabain, and the ability of various agents to produce reversion to normal sinus rhythm has been tested. Diphenylhydantoin sodium, procaine amide hydrochloride, procaine hydrochloride and quinidine hydrochloride were approximately equally effective; however the procaine hydrochloride effect was shorter and the drug was more toxic than the other three. It is suggested that diphenylhydantoin sodium may merit a trial for the treatment of digitalis-induced ventricular arrhythmias.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference3 articles.
1. 1WITHERING W.: An account of the foxglove. London 1785. Reprinted in Medical Classics. Baltimore Williams & Wilkins 1937-38. Vol. 2.
2. Digitalis Poisoning and Its Treatment
3. Effectiveness of Procaine Amide in Digitalis-Induced Ventricular Tachycardia.
Cited by
84 articles.
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