The Influence of Hypertonic Saline Infusions Upon the Fractional Reabsorption of Urate and Other Ions in Normal and Hypertensive Man

Abstract

Renal hemodynamics and the excretion rates of six ions were studied in a group of 24 normotensive and hypertensive subjects during expansion of extracellular fluid volume (ECF) with intravenous infusions of hypertonic saline. In response to the 2.5% saline infusions arterial blood pressure did not change from control values, but glomerular filtration rate increased, and renal vascular resistance decreased. Accompanying these hemodynamic alterations the urinary excretion rates of sodium, calcium, magnesium, potassium, chloride, and urate increased significantly. Net fractional reabsorption of the six ions fell significantly below control values. The induced changes in net Ca, Mg, K, Cl, and urate reabsorption in all the subjects were directly and significantly related to the simultaneous depression of Na reabsorption. The data indicate that increased excretion and net tubular rejection of urate accompany depression of tubular sodium reabsorption during hypertonic saline infusions in normal and hypertensive man. The nonspecificity of depressed fractional ion reabsorption during the infusions is compatible with the hypothesis that physical forces which alter fluid uptake by peritubular capillaries determine to a significant extent the natriuretic response of the human nephron to hypertonic saline infusions. Alternatively, if a natriuretic hormone elicited by ECF volume expansion in man accounts for the depressed fractional Na reabsorption, the data imply that directly or indirectly this substance inhibits net fractional reabsorption of a variety of other ions.