Mean Coronary Cross‐Sectional Area as a Measure of Arterial Remodeling Using Noncontrast CT Imaging in Persons With HIV

Author:

Werede Ayoda T.1,Terry James G.2ORCID,Nair Sangeeta2,Temu Tecla M.3,Shepherd Bryan E.4,Bailin Samuel S.1ORCID,Mashayekhi Mona5ORCID,Gabriel Curtis L.6,Lima Morgan1,Woodward Beverly Owen1,Hannah LaToya1ORCID,Mallal Simon A.178ORCID,Beckman Joshua A.9ORCID,Li Jonathan Z.10,Fajnzylber Jesse10ORCID,Harrison David G.11ORCID,Carr John Jeffrey2ORCID,Koethe John R.112,Wanjalla Celestine N.1ORCID

Affiliation:

1. Division of Infectious Diseases Vanderbilt University Medical Center Nashville TN

2. Department of Radiology Vanderbilt University Medical Center Nashville TN

3. Departments of Global Health University of Washington Seattle WA

4. Department of Biostatistics Vanderbilt University Medical Center Nashville TN

5. Division of Diabetes, Endocrinology and Metabolism Vanderbilt University Medical Center Nashville TN

6. Division of Gastroenterology Vanderbilt University Medical Center Nashville TN

7. Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center Nashville TN

8. Department of Biomedical Informatics Vanderbilt University Medical Center Nashville TN

9. Division of Cardiology Vanderbilt University Medical Center Nashville TN

10. Center for AIDS Research Clinical Core Brigham and Women’s Hospital Boston MA

11. Division of Clinical Pharmacology Vanderbilt University Medical Center Nashville TN

12. Veterans Affairs Tennessee Valley Healthcare System Nashville TN

Abstract

Background Persons with HIV have a higher prevalence of coronary artery disease compared with their HIV‐negative counterparts. Earlier identification of subclinical atherosclerosis may provide a greater opportunity for cardiovascular disease risk reduction. We investigated coronary cross‐sectional area (CorCSA) by noncontrasted computed tomography imaging as a noninvasive measure of arterial remodeling among virally suppressed persons with HIV. Methods and Results We assessed 105 persons with HIV with a spectrum of cardiometabolic health. All participants underwent computed tomography imaging to assess the mean corCSA of the proximal left anterior descending artery and 28 participants underwent additional coronary computed tomography angiography. Partial Spearman rank correlations adjusted for cardiovascular disease risk factors were used to assess relationships of corCSA with anthropometric measurements, HIV‐related factors, and plasma cytokines. Mean corCSA measured by noncontrast computed tomography and coronary computed tomography angiography were strongly correlated (ρ=0.91, P <0.0001). Higher mean corCSA was present in those with coronary artery calcium ( P =0.005) and it correlated with participants' atherosclerotic cardiovascular disease risk score (ρ=0.35, P =0.01). After adjusting for established cardiovascular disease risk factors, we observed an inverse relationship between corCSA and CD4 + T‐cell count (ρ=−0.2, P =0.047). Removal of age from the model strengthened the relationships between corCSA and antiretroviral therapy duration (from ρ=0.19, P =0.08 to ρ=0.3, P =0.01). CorCSA was also inversely correlated with plasma IL‐10 (ρ=−0.25, P =0.03) but had no relationship with IL‐6 (ρ=0.11, P =0.4) or IL‐1β (ρ=0.08, P =0.5). Conclusions Positive coronary arterial remodeling, an imaging marker of subclinical atherosclerosis, is associated with a lower CD4 T‐cell count, lower circulating IL‐10, and possibly a longer antiretroviral therapy duration in persons with HIV. Registration Clinicaltrials.gov; Unique identifier: NCT04451980.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3