Hepatic Venous Stasis Index Reflects Hepatic Congestion and Predicts Adverse Outcomes in Patients With Heart Failure

Author:

Ohara Himika1ORCID,Yoshihisa Akiomi12ORCID,Ishibashi Shinji3,Matsuda Mitsuko3,Yamadera Yukio3,Sugawara Yukiko1,Ichijo Yasuhiro1ORCID,Sato Yu1ORCID,Misaka Tomofumi1ORCID,Sato Takamasa1ORCID,Oikawa Masayoshi1,Kobayashi Atsushi1,Takeishi Yasuchika1ORCID

Affiliation:

1. Department of Cardiovascular Medicine Fukushima Medical University School of Medicine Fukushima Japan

2. Department of Clinical Laboratory Sciences Fukushima Medical University School of Health Science Fukushima Japan

3. Department of Clinical Laboratory Medicine Fukushima Medical University Hospital Fukushima Japan

Abstract

Background It has been reported that the hepatic vein waveforms determined by abdominal ultrasonography can assess hepatic congestion in patients with heart failure (HF). However, the parameter that quantifies hepatic vein waveforms has not been established. We suggest the hepatic venous stasis index (HVSI) as the novel indicator to evaluate hepatic congestion quantitatively. To examine the clinical significance of HVSI in patients with HF, we aimed to clarify the associations of HVSI with the parameters of cardiac function and right heart catheterization, as well as that with prognosis, in patients with HF. Methods and Results We performed abdominal ultrasonography, echocardiography, and right heart catheterization in patients with HF (n=513). The patients were divided into 3 groups based on HVSI as follows: HVSI 0 (HVSI=0, n=253), low HVSI (HVSI 0.01–0.20, n=132), and high HVSI (HVSI>0.20, n=128). We examined the associations of HVSI with parameters of cardiac function and right heart catheterization and followed up for cardiac events defined as cardiac death or worsening HF. There was a significant increase in level of B‐type natriuretic peptide, inferior vena cava diameter, and mean right atrial pressure with increasing HVSI. During the follow‐up period, cardiac events occurred in 87 patients. In the Kaplan–Meier analysis, cardiac event rate increased across increasing HVSI (log‐rank, P =0.002). Conclusions HVSI assessed by abdominal ultrasonography reflects hepatic congestion and right‐sided HF and is associated with adverse prognosis in patients with HF.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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