The Prognostic Value of B‐Type Natriuretic Peptide in Patients With Cardiac Sarcoidosis Without Heart Failure: Insights From ILLUMINATE‐CS

Author:

Miyakuni Shota12ORCID,Maeda Daichi1ORCID,Matsue Yuya1ORCID,Yoshioka Kenji2,Dotare Taishi1ORCID,Sunayama Tsutomu1,Nabeta Takeru3ORCID,Naruse Yoshihisa4ORCID,Kitai Takeshi5ORCID,Taniguchi Tatsunori6,Tanaka Hidekazu7,Okumura Takahiro8ORCID,Baba Yuichi9ORCID,Matsumura Akihiko2,Minamino Tohru110ORCID

Affiliation:

1. Department of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan

2. Department of Cardiology Kameda Medical Center Chiba Japan

3. Department of Cardiovascular Medicine Kitasato University School of Medicine Sagamihara Japan

4. Division of Cardiology, Internal Medicine III Hamamatsu University School of Medicine Hamamatsu Japan

5. Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center Osaka Japan

6. Department of Cardiovascular Medicine Osaka University Graduate School of Medicine Osaka Japan

7. Division of Cardiovascular Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Japan

8. Department of Cardiology Nagoya University Graduate School of Medicine Nagoya Japan

9. Department of Cardiology and Geriatrics, Kochi Medical School Kochi University Nankoku Japan

10. Japan Agency for Medical Research and Development‐Core Research for Evolutionary Medical Science and Technology (AMED‐CREST) Japan Agency for Medical Research and Development Tokyo Japan

Abstract

Background The prognostic role of BNP (B‐type natriuretic peptide) in patients with cardiac sarcoidosis without evident heart failure is unknown. Methods and Results This is a post hoc analysis of ILLUMINATE‐CS (Illustration of the Management and Prognosis of Japanese Patients With Cardiac Sarcoidosis), a multicenter, retrospective, and observational study that evaluated the clinical characteristics and prognosis of cardiac sarcoidosis. We analyzed patients with cardiac sarcoidosis without evident heart failure at the time of diagnosis. The association between baseline BNP levels and prognosis was investigated. The primary end point was the combined end point of all‐cause death, heart failure hospitalization, and fatal ventricular arrhythmia. In total, 238 patients (61.0±11.1 years, 37% men) were analyzed, and 61 primary end points were observed during a median follow‐up period of 3.0 (interquartile range, 1.7–5.8) years. Patients with high BNP (BNP above the median value of BNP) were older and had a lower renal function and left ventricular ejection fraction than those with low BNP values. Kaplan–Meier curve analysis indicated that high BNP levels were significantly associated with a high incidence of primary end points (log‐rank P =0.004), and this association was retained even in multivariable Cox regression (hazard ratio, 2.06 [95% CI, 1.19–3.55]; P =0.010). Log‐transformed BNP as a continuous variable was associated with the primary end point (hazard ratio, 2.12 [95% CI, 1.31–3.43]; P =0.002). Conclusions High baseline BNP level was an independent predictor of future adverse events in patients with cardiac sarcoidosis without heart failure at the time of diagnosis. Registration URL: https://www.umin.ac.jp/english/ ; Unique Identifier: UMIN‐CTR: UMIN000034974.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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