Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis-Reference-Cited by-同舟云学术

Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis

Published:2023-03-21 Issue:6 Volume:12 Page:
ISSN:2047-9980
Container-title:Journal of the American Heart Association
language:en
Short-container-title:JAHA

Author:

Ueberham Laura¹^ORCID,Hagendorff Andreas¹^ORCID,Klingel Karin²^ORCID,Paetsch Ingo³^ORCID,Jahnke Cosima³^ORCID,Kluge Theresa⁴,Ebbinghaus Hans³,Hindricks Gerhard³,Laufs Ulrich¹^ORCID,Dinov Borislav³

Affiliation:

1. Klinik und Poliklinik für Kardiologie Universitätsklinikum Leipzig Leipzig Germany

2. Cardiopathology Institute for Pathology, Eberhard Karls Universität Tübingen Tübingen Germany

3. Department of Electrophysiology Heart Center Leipzig at University of Leipzig Leipzig Germany

4. Klinik und Poliklinik für Nuklearmedizin Universitätsklinikum Leipzig Leipzig Germany

Abstract

Cardiac sarcoidosis can mimic any cardiomyopathy in different stages. Noncaseating granulomatous inflammation can be missed, because of the nonhomogeneous distribution in the heart. The current diagnostic criteria show discrepancies and are partly nonspecific and insensitive. Besides the diagnostic pitfalls, there are controversies in the understanding of the causes, genetic and environmental background, and the natural evolution of the disease. Here, we review the current pathophysiological aspects and gaps that are relevant for future cardiac sarcoidosis diagnostics and research.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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