Affiliation:
1. Department of Cardiovascular Diseases Mayo Clinic Rochester MN United States
2. Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN United States
Abstract
Background
A high prevalence of preclinical heart failure (HF) (Stages A and B) has previously been shown. The aim of this study was to explore factors associated with the incidence of preclinical HF in a community population.
Methods and Results
Retrospective review of 393 healthy community individuals aged ≥45 years from the Olmsted County Heart Function Study that returned for 2 visits, 4 years apart. At visit 2, individuals that remained normal were compared with those that developed preclinical HF. By the second visit, 191 (49%) developed preclinical HF (12.1 cases per 100 person‐years of follow‐up); 65 (34%) Stage A and 126 (66%) Stage B. Those that developed preclinical HF (n=191) were older (
P
=0.004), had a higher body mass index (
P
<0.001), and increased left ventricular mass index (
P
=0.006). When evaluated separately, increased body mass index was seen with development of Stage A (
P
<0.001) or Stage B (
P
=0.009). Echocardiographic markers of diastolic function were statistically different in those that developed Stage A [higher E/e’ (
P
<0.001), lower e’ (
P
<0.001)] and Stage B [higher left atrial volume index (
P
<0.001), higher E/e’ (
P
<0.001), lower e’ (
P
<0.001)]. NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) was higher at visit 2 in those that developed Stage A or B (
P
<0.001 for both). Hypertension (57%), obesity (34%), and hyperlipidemia (25%) were common in the development of Stage A. Of patients who developed Stage B, 71% (n=84) had moderate or severe diastolic dysfunction.
Conclusions
There is a high incidence of preclinical HF in a community population. Development of Stage A was driven by hypertension and obesity, while preclinical diastolic dysfunction was seen commonly in those that developed Stage B.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
4 articles.
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