Smoking is Associated to DNA Methylation in Atherosclerotic Carotid Lesions

Author:

Siemelink Marten A.1,van der Laan Sander W.1,Haitjema Saskia2,van Koeverden Ian D.1,Schaap Jacco1,Wesseling Marian1,de Jager Saskia C.A.13,Mokry Michal4,van Iterson Maarten5,Dekkers Koen F.5,Luijk René56,Foroughi Asl Hassan7,Michoel Tom8,Björkegren Johan L.M.79,Aavik Einari10,Ylä-Herttuala Seppo11,de Borst Gert J.12,Asselbergs Folkert W.13141516,el Azzouzi Hamid,den Ruijter Hester M.1,Heijmans Bas T.5,Pasterkamp Gerard2

Affiliation:

1. Laboratory of Experimental Cardiology, University Medical Center Utrecht, University of Utrecht, the Netherlands (M.A.S., S.W.v.d.L., I.D.v.K., J.S., M.W., S.C.A.d.J., H.M.d.R.)

2. Laboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, University of Utrecht, the Netherlands (S.H., G.P.)

3. Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, the Netherlands (S.C.A.d.J.),

4. Division Pediatrics, Wilhelmina Children’s Hospital, University Medical Center Utrecht, University of Utrecht, the Netherlands (M.M.)

5. Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, 2333 ZC, the Netherlands (M.v.I., K.F.D., R.L., B.T.H.)

6. Medical Statistics, Biomedical Data Sciences, Leiden University Medical Center, Leiden, 2333 ZC, the Netherlands (R.L.).

7. Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden (H.F.A., J.L.M.B.).

8. Division of Genetics and Genomics, The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, United Kingdom (T.M.).

9. Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden, Clinical Gene Networks AB, Stockholm, Sweden (J.L.M.B.)

10. Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, University of Eastern Finland, Finland (E.A.).

11. A. I. Virtanen Institute, University of Eastern Finland, 70210, Kuopio, Finland, Heart Center and Gene Therapy Unit, Kuopio University Hospital, 70210 Kuopio, Finland (S.Y.-H.).

12. Department of Vascular Surgery, University Medical Center Utrecht, University of Utrecht, the Netherlands (G.J.d.B.),

13. Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, the Netherlands (F.W.A.)

14. Durrer Center for Cardiogenetic Research, Netherlands Heart Institute, Utrecht, the Netherlands (F.W.A.).

15. Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, United Kingdom (F.W.A.).

16. Institute of Health Informatics, University College London, London, United Kingdom (F.W.A.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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