Affiliation:
1. From The Permanente Medical Group, Kaiser Foundation Hospital, Sacramento, Calif.
Abstract
Background
—Ethical issues are a critical consideration in the design and conduct of clinical research.
Summary of Review
—A number of completed trials of proposed stroke treatments raise classical ethical issues in challenging ways. The combination of acutely ill and vulnerable patients, the use of potentially toxic drugs, and very short time frames for decision making and drug administration demand an especially careful evaluation of risk and benefit, the process of consent, and the permissible treatment of control patients.
Conclusions
—The study of acute stroke treatments may require more complex safeguards than other neuroclinical trials.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)
Reference66 articles.
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2. The Validity of Rodent Brain-Ischemia Models Is Self-evident
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