Affiliation:
1. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2182.
Abstract
There are two types of heparin-induced thrombocytopenia. Type I is more common, has an early onset, and is mild, transient, and benign. Type I is due to direct heparin-induced platelet aggregation and is rarely associated with thromboembolic sequela. Type II is infrequent, has a late onset, and is more severe. Type II is due to an immune-mediated platelet aggregation caused by IgG and IgM that becomes bound to platelets. In Type II, the antibody titers decline over several months; however, early reexposure can result in a catastrophic secondary immune response. Frequently, Type II is associated with life- or limb-threatening thromboembolic complications (white clots), including stroke.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology
Reference161 articles.
1. Thrombocytopenia Occurring during Heparin Therapy
2. Heparin-induced thrombocytopenia and recurrent thromboembolism
3. Thrombosis and thrombocytopenia induced by heparin;Carreras LO;Scand J Haematol,1980
4. Report of the International Committee on Thrombosis and Haemostasis. Thrombocytopenia and heparin;Godal HC;Thromb Haemost,1980
5. Heparin-Associated Thrombocytopenia
Cited by
65 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献