Neurological and Functional Outcome in Patients With Supratentorial Hemorrhages

Abstract

Background and Purpose A prospective study was performed to evaluate neurological and functional outcome after spontaneous supratentorial bleeding. The aim of the study was to determine whether clinical or neuroradiological parameters could predict the outcome of these patients during the first hours of hospitalization. Methods Two hundred seventy-nine patients—52 with thalamic, 87 with putaminal, and 140 with lobar hemorrhages—were followed prospectively and examined on admission and at 2 weeks, 3 months, and 6 months after onset. The patients underwent clinical (according to the Glasgow Coma Scale) and neuroradiological examinations on admission and were scored clinically and functionally (according to Stroke Severity score and Barthel Index) on the follow-up periods. Risk factors and the correlation between findings on admission and the latest clinical and functional results were calculated with the χ 2 test, Pearson correlation test, and Student’s t test. Multivariate analysis was calculated with the stepwise regression test. Results In all of the bleeding locations, lethal outcome was significantly correlated with size of the hematoma ( P <.001) and Glasgow Coma Scale score on admission ( P <.001). Intraventricular blood expansion was found to have a better prognosis in thalamic bleeding ( P <.007) and a worse prognosis in lobar hemorrhage ( P <.01). The functional outcome after 6 months was directly correlated with the size of the bleeding area in lobar and putaminal hemorrhages. No correlation was found in thalamic bleeding. A worse functional outcome was found in putaminocapsular bleeding ( P =.004) and in patients with ischemic heart disease. A limited better recovery prognosis was found in patients with lobar hematoma in the temporal lobe ( P =.052). Conclusions The probability of lethal outcome can be calculated on admission in all patients with supratentorial bleeding and in correlation with the location and size of the bleeding area and level of consciousness. Intraventricular expansion of blood is a better prognostic factor in thalamic bleeding and a worse one in lobar hematoma. Functional outcome is correlated with size of the bleeding area and level of consciousness on admission in putaminal and lobar hemorrhages but has no correlation to thalamic hemorrhage.