Affiliation:
1. From the Institut für Anatomie der Universität Rostock (Germany).
Abstract
Background and PurposeThe present investigation aimed to quantify functional activity in rat brains after long-term recovery from transient forebrain ischemia.MethodsWith the use of the [14C]2-deoxyglucose method, local cerebral glucose utilization was measured in 62 cortical and subcortical brain regions in postischemic rat brains. Transient forebrain ischemia of 10 minutes’ duration was induced by clamping the common carotid arteries and simultaneously lowering blood pressure to 40 mm Hg. Rats survived the insults for 1 week, 2 weeks, 3 weeks, or 3 months.ResultsReductions predominated in the majority of gray matter structures at all time points investigated (P<.05). Except for a few areas, recoveries of local cerebral glucose utilization to preischemic levels did not occur.ConclusionsThe data illustrate that widespread alterations of functional activity prevail in postischemic brains beyond the selectively vulnerable regions. The present functional data are in line with previous stereological results of reduced fresh volumes in the majority of postischemic brain structures. The data suggest that chronic alterations of ischemic brains are not confined to the selectively vulnerable regions.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)
Cited by
13 articles.
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