1. From the Department of Geriatrics (M.K., M.A.R., S.K., T.K., T.A., K.M., A.I.), Nagoya University Graduate School of Medicine, Nagoya, the Tokyo Research Laboratories of Kyowa Hakko Kogyo Co (K.S.), Machida, and the Department of Genetics (M.S.), Institute of Medical Science, University of Tokyo, Tokyo, Japan.