Affiliation:
1. From Centre for Eye Research Australia (N.C., S.R., T.Y.W.), University of Melbourne, Australia; Department of Biostatistics (D.J.C.), University of North Carolina, Chapel Hill, NC; Department of Ophthalmology (R.K.), University of Wisconsin, Madison, Wis; Department of Epidemiology (A.R.S.), Johns Hopkins University, Baltimore, Md; Singapore Eye Research Institute (T.Y.W.), National University of Singapore.
Abstract
Background and Purpose—
The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study.
Methods—
A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic stroke events were prospectively identified and validated.
Results—
Over an average follow-up of 7.8 years, there were 75 ischemic stroke events. After adjustment for age, gender, race, center, 6-year mean arterial blood pressure, anti-hypertensive treatment use, fasting glucose, insulin treatment, duration of diabetes, high-density lipoprotein and low-density lipoprotein cholesterol levels and cigarette smoking status, diabetic retinopathy was associated with an increased risk of ischemic stroke (hazard rate ratio, 2.34; 95% CI, 1.13 to 4.86).
Conclusions—
Diabetic retinopathy predicts incident ischemic stroke in people with diabetes, independent of other risk factors.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)
Cited by
133 articles.
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