1. From the Departments of Epidemiology & Biostatistics (F.A.S.-T., M.J.E.v.R., Y.S.A., E.A.C., M.C.Z., J.C.M.W., C.M.v.D.), Internal Medicine (A.F.C.S., M.C.Z., H.A.P.P.), and Clinical Genetics (B.A.O.), Erasmus Medical Centre, Rotterdam, The Netherlands.