1. From the Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital (M.A., T.K., K.B., J.E.B.) and Department of Ambulatory Care and Prevention (J.E.B.), Harvard Medical School, Boston, Mass; Department of Epidemiology, Harvard School of Public Health, Boston, Mass (T.K., J.E.B.); Institute of Epidemiology and Social Medicine (K.B.), University of Muenster, Muenster, Germany; and Department of Neurology, Boston University Medical Center, Boston, Mass (C.S.K.).