Effects of Regitine (C-7337) in Patients, Particularly Those with Peripheral Arterial Vascular Disease

Abstract

This is a study of the clinical effects of Regitine, a new antiadrenergic drug, the pharmacologic properties of which are similar to those of Priscoline. Thirty-four patients, whose diagnoses fall into the peripheral vascular disease group and into a miscellaneous group were first given thedrug intravenously and the responses were studied with skin temperature recordings in an attempt to predict the response to therapeutic administration of Regitine. The drug was then given orally for varying periods of time, with subjective and objective evidences of response, as well as side effects being noted. The results of these observations are set forth in the paper.