Abstract
The occurrence of ventricular fibrillation after occlusion of the circumflex coronary artery in the conscious dog was examined as one preparation for sudden cardiac death arising from coronary artery disease. The incidence of ventricular fibrillation after after circumflex occlusion was reduced from 53% to 6% (p less than .01) by the infusion of prostacyclin in doses that do not alter cardiac output or peripheral resistance. This effect of prostacyclin led to the evaluation of two structurally different inhibitors of thromboxane synthase in this preparation; RO 22-4679 and U-63557A reduced ventricular fibrillation by 82% and 100%, respectively (p less than .05). The inhibition of ventricular fibrillation by U-63557A was abrogated by pretreatment with indomethacin, suggesting that a metabolite of the endoperoxide that accumulated during thromboxane synthase inhibition was responsible for the protection from ventricular fibrillation.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference15 articles.
1. Sudden cardiac death: A decade's experience without hospital resuscitation;Cobb LA;Mod Concepts Cardiovasc Dis,1980
2. Thrombosis and Acute Coronary-Artery Lesions in Sudden Cardiac Ischemic Death
3. Jorgenson L: The role of platelet embolism from crumbling thrombic and platelet aggregates arising in flowing blood. In Sherry S Brinkhous KM Genton E editors: Thrombosis. Washington D.C. 1969 National Academy of Science p 506
4. Mural platelet microthrombi and major acute lesions of main epicardial arteries in sudden coronary death
5. Administration of Prostacyclin Prevents Ventricular Fibrillation Following Coronary Occlusion in Conscious Dogs
Cited by
39 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献