Affiliation:
1. From the Quincy City Hospital, Quincy, Mass., and the Kent General Hospital, Dover, Del.
Abstract
Cholesterol is absorbed by rabbits while its stereoisomer, sitosterol, is not resorbed. Cholesterol and sitosterol form nonseparable crystals. When the two sterols were fed simultaneously to rabbits, cholesterol was not absorbed, or was absorbed but partly. The degree of prevention of hypercholesteremia depended upon the amount of sitosterol fed with the cholesterol. A six-fold surplus of plant sterol was required in the experiments because the product employed contained but 75 to 80 per cent of sitosterol and because the supplied sitosterol binds not only exogenous cholesterol but also endogenous cholesterol present in the intestines. In the rabbit, prevention of hypercholesteremia is tantamount to prevention of atherosclerosis induced by cholesterol feeding.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference21 articles.
1. VON GIERKE: Discussion of papers I-XIII 20th meeting Wfirzburg April 1-3 1925. Verhandl. deutsch. Path. Ges. 20: 159 1925.
2. The physiological action of phytosterol esters;NIKUNI J.;J. Agric. Chem. Soc. Japan,1931
3. {ober das Schicksal des Cholesterins im thierischen Organismus. Ztschr. physiol;BONDZYNSKI S.;Chem.,1896
4. 4DORRE C. AND GARDNER J. A.: The origin and destiny of cholesterol in the animal organism. Part I. On the so-called hippocoprosterol. Proc. Roy. Soc. London s.B. 80: 212 1908.
5. 5FRASER MI. T. AND GARDNER J. A.: The origin and destiny of cholesterol in the animal organism. Part VII. On the quantity of cholesterol and cholesterol esters. Proc. Roy. Soc. London s.B. 82: 559 1910.
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