1. From the Department of Clinical Cell Biology (F5) (Y.Z., S.H., T.K., K.T., M.S., Y.S.) and the Department of Genome Research and Clinical Application (M6) (H.B.), Chiba University Graduate School of Medicine, Chiba, Japan; Kowa Research Institute, Kowa Co Ltd (H.Y.), Tokyo, Japan; and the Department of Molecular Genetics, Biocenter and University of Vienna (S.H., W.J.S), Vienna, Austria.