1. From the Department of Medicine (Cardiovascular Research), St Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, Mass (R.P., T.R.A., E.B., M.B.-M., C.C., M.K., J.M.I., D.W.L.); the Department of Medicine, A. Gemelli University Hospital, Rome, Italy (R.P.); and Biogen, Inc, Cambridge, Mass (L.E.L., M.C.).