1. From the Harvard Clinical Research Institute, Boston, Mass (D.J.C., A.B., C.S., L.G., T.L., R.H.B., R.E.K.); Division of Cardiology, Beth Israel-Deaconess Medical Center, Boston, Mass (D.J.C., A.B., J.P.C.); Clinical Trials and Evaluation Unit, Royal Brompton Hospital, London, UK (A.B.); Lenox Hill Hospital, New York, NY (M.B.L., J.W.M.); and Duke University Medical Center, Durham, NC (J.P.Z.).