1. From the Centre for Cardiovascular Science (J.G., N.R.J., A.D.C., D.J.W.), University of Edinburgh, Edinburgh, United Kingdom; Monklands Hospital (M.F.H.), Airdrie, Lanarkshire, United Kingdom; Department of Nephrology & Hypertension (T.J.R.), University Hospital, Utrecht, Netherlands; and Pfizer Global Research & Development (A.J.R.), Sandwich, United Kingdom.