1. From the Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology (E.S., R.M., R.H.B.), Institute of Clinical Chemistry (J. Brümmer), and Institute of Mathematics and Data Processing in Medicine (J. Berger), University Hospital Hamburg-Eppendorf, and the Institute of Clinical Pharmacology (A.B., H.L., D.T., F.-M.G., J.C.F.), Hannover Medical School, Germany.