1. From the Departments of Internal Medicine (A.S.W., T.M.M., G.A.Z., S.M.P.) and Pathology (M.M.D., T.M.M.), Eccles Institute of Human Genetics (A.S.W., M.M.D., J.R.K.-E., E.D.S., G.K.M., T.M.M., G.A.Z.), and the Huntsman Cancer Institute (S.M.P.), University of Utah, Salt Lake City; and the Department of Biological Sciences, University of South Carolina, Columbia (D.A.D.).