1. From the University of Alberta (P.K., P.W.A., W.-C.C.), Edmonton, Alberta, Canada; the University of Toronto (C.D.N.), Toronto, Ontario, Canada; Duke Clinical Research Institute (P.K., C.B.G., K.L.L., E.D.P., R.M.C., D.B.M.), Durham, NC; and the Cleveland Clinic Foundation (E.J.T.), Cleveland, Ohio.