Author:
I Putu Alit Pawana ,Martha Kurnia Kusumawardani ,Lydia Arfianti
Abstract
ABSTRACTIntroduction: The aim of this study was to explore the effect of adding oral curcumin to resistance exerciseafter immobilization on the diameter of skeletal muscle fiber in Rattus Norvegicus.Methods: This was a post-test only study design on animal model. Subjects of the study were male Rattusnorvegicus strain Wistar, age 10-12 weeks old, weigh between 150-300 g, were immobilized at soleusmuscle for 2 weeks, then randomly allocated to 3 groups: (i) control group, (ii) resistance exercise, (iii)oral curcumin + resistance exercise. After 4 weeks of intervention, the diameter of the muscle fibers wasmeasured.Result: The results of this study showed a significant difference on the diameter of skeletal muscle fiberbetween control group and resistance exercise, as well as control group and resistance exercise + oralcurcumin (p<0.05). There was no significant difference between resistance exercise only and resistanceexercise + oral curcumin (p>0.05).Conclusion: Administration of oral curcumin to resistance exercise after immobilization does not affectskeletal muscle fiber diameter in Rattus Norvegicus.Keywords : curcumin, good health and well-being, immobilization, resist ance exercise, skeletal muscle.
Publisher
Indonesian Physical Medicine and Rehabilitation Association
Subject
Microbiology (medical),Immunology,Immunology and Allergy
Reference25 articles.
1. Lolascon G, Paoletta M, Liguori S, Curci C, Moretti A. Neuromuscular diseases and bone. Front Endocrinol 2019; 10(11): 794.
2. Appell H-J. Muscular atrophy following immobilization. Sport Med 1990; 10(1): 42–58. Figure 4. Example of a histopathological longitudinal cross section of soleus muscle from the resistance exercise group (Magnification x 400)Figure 5.Example of a histopathological cross-section of the soleus muscle from the resistance exercise group plus oral curcumin (Magnification x 400)
3. Atherton PJ, Greenhaff PL, Phillips SM, Bodine SC, Adams CM, Lang CH. Control of skeletal muscle atrophy in response to disuse: Clinical/preclinical contentions and fallacies of evidence. Am J Physiol - Endocrinol Metab 2016; 311(3): E594–604.
4. Jackman RW, Kandarian SC. The molecular basis of skeletal muscle atrophy. Am J Physiol Cell Physiol 2004; 287(4): C834–C843.
5. Gao Y, Arfat Y, Wang H, Goswami N. Muscle atrophy induced by mechanical unloading: Mechanisms and potential countermeasures. Front Physiol 2018; 9(3).